This report provides an overview of fiscal year 2022 activities at the IDA Science and Technology Policy Institute (STPI). STPI provides an independent, objective source of analyses for the White House Office of Science and Technology Policy and several other organizations in the federal government. The report provides highlights of STPI’s projects in the following categories: federal science and technology policy; space technology and policy; STEM education, workforce, and talent; biosciences and public health; environment; emerging technologies and technology transition; and agency program development and portfolio evaluations.